Cancer Genomics and Mathematical Data Analysis Symposium

About

The symposium on Cancer Genomics and Mathematical Data Analysis, co-organized by Columbia PSOC (Directors Drs Rabadan & Iavarone), MSK CSBC (Directors Dr Leslie & Rudensky), Columbia CSBC (Directors Drs Califano & Honig) and Cornell PSOC (Drs Fischbach-Teschl & Cantley) will present a comprehensive overview of algorithmic and mathematical approaches to the study of cancer through genomic approaches.

The symposium includes a satellite session on Understanding the dream challenge and a poster session with Poster Prizes sponsored by Cancer Reports – a new broad scope journal for basic, translational, clinical and interdisciplinary cancer research published by Wiley.

For any questions or concerns please contact Sophie Thuault-Restituito at st3090@cumc.columbia.edu or (646)-341-2019

Speakers

Andrew Blumberg, PhD (University of Texas at Austin)
Andrea Califano, PhD (Columbia University)
Olivier Elemento, PhD (Weill Cornell Medicine)
Adolfo Ferrando, PhD (Columbia University)
Raluca Gordan, PhD (Duke University)
Barry Honig, MD (Columbia University)
Marcin Imielinski, PhD (Weill Cornell Medicine)
Anna Lassorella, PhD (Columbia University)
Ashley Laughney, PhD ( Memorial Sloan Kettering)
Michael Shen, PhD (Columbia University)
Peter Sims, PhD (Columbia University)
Simon Tavare, PhD (Cancer Research UK Cambridge Institute)
Jeffrey Varner, PhD (Cornell University)
Joao Xavier, PhD (Memorial Sloan Kettering)

The symposium will also include an overview of DREAM challenges and a poster session.

Satellite Session Program

Wednesday February 7th:

Satellite session: Understanding the Dream Challenge
Riverview Terrace, 173 Fort Washington Ave, NY, NY10032
Chair: Diana Murray

9:00-9:30 am - Coffee/Tea & Registration
9:30-10:00 am - Justin Guinney, PhD, Director, Sage Bionetworks.
Introduction to and history of DREAM challenges.
10:00-10:45 am - Dimitris Anastassiou, PhD, Columbia University.
Metagenes: Prognosis of breast cancer and beyond.
10:45-11:00 am - Coffee break
11:00-11:30 am - Michael Stokes, PhD, Columbia University.
Subtype-Selective Lethal Molecules Disrupt the Regulatory Network That Drives Neuroblastoma.
11:30am-12:00 pm - Eugene Douglass, PhD, Columbia University.
The network logic of drug-response and resistance.
12:00-12:45 pm - Discussion led by Sage Bionetworks.
Creating DREAM Challenges based on data from the Centers for Cancer Systems Therapeutic and Topology of Cancer Evolution and Heterogeneity in the Department of Systems Biology at Columbia University Medical Center

Symposium Program

Wednesday February 7th:

1:15-1:45 pm – Registration
1:45-2:00 pm - Introduction of the 4 Centers co-organizing the Symposium
2:00-2:40 pm - Olivier Elemento, PhD, Weill Cornell Medicine
A cancer precision medicine program driven by multi-omics, analytics and modeling
2:40-3:20 pm - Peter Sims, PhD, Columbia University
Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma
3:20-4:00 pm - Raluca Gordan, Ph.D. Duke University
Quantifying the impact of non-coding mutations on transcriptional regulation
4:00-4:40 pm - Andrea Califano, PhD, Columbia University
Elucidating druggable cancer dependencies on an individual cell basis

Session 2:
Riverview Terrace, 173 Fort Washington Ave, NY, NY10032

5:00-8:00 pm - Poster session and networking event, wine & cheese.
Prize sponsored by Cancer Reports

Thursday, February 8th:

Session 3:
Heart Conference Center, 1st Floor, 173 Fort Washington Ave, NY, NY 10032
Chair: Raul Rabadan

8:30-9:00 am - Coffee/Tea & Registration
9:00-9:40 am - Simon Tavare, PhD, Cancer Research UK Cambridge Institute
Inferring modes of cancer evolution from DNA sequencing data
9:40-10:20 am - Anna Lassorella, PhD, Columbia University
10:20-11:00 am - Andrew Blumberg, PhD, University of Texas at Austin
Mathematical tools for inference in spaces of phylogenetic trees
11:00-11:20 am - Coffee/tea break
11:20-12:00 pm - Barry Honig, PhD, Columbia University
Using three-dimensional structure to predict protein-protein and protein-ligand interactions
12:00-12:40 pm - Marcin Imielinski, PhD, Weill Cornell Medicine
Recurrent patterns of rearrangement across 3000 cancer graph genomes
12:40-2:00 pm - Lunch: on your own

Session 4:
Heart Conference Center, 1st Floor, 173 Fort Washington Ave, NY, NY 10032
Chair: Lew Cantley

2:00-2:40 pm - Joao Xavier, PhD, Memorial Sloan Kettering
Mathematical ecology to predict cancer outcomes
2:40-3:20 pm - Jeff Varner, PhD, Cornell University
Modeling the Integration of Metabolism and Signal Transduction using a Dynamic Constraint Based Approach
3:20-4:00 pm - Ashley Laughney, PhD, Memorial Sloan Kettering
Dissecting tumor cell plasticity and population interactions supporting metastasis using single cell genomics
4:00-4:20 pm - Coffee/tea break

Session 5:
Heart Conference Center, 1st Floor, 173 Fort Washington Ave, NY, NY 10032
Chair: Antonio Iavarone

4:20-5:00 pm - Adolfo Ferrando, PhD, Columbia University
5:00-5:40 pm - Michael Shen, PhD, Columbia University
Mouse models of prostate tumor evolution
5:40-6:20 pm - Concluding remarks

Location

Columbia University
Heart Conference Center, 1st Floor
173 Fort Washington Ave
New York, NY 10032